1 | ;; |
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2 | ;; Morris-Lecar model |
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3 | ;; |
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4 | |
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5 | (use mathh sundials srfi-4) |
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6 | |
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7 | |
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8 | (define TEND 500.0) |
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9 | |
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10 | |
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11 | ;; Model parameters |
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12 | |
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13 | (define Istim 20) |
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14 | (define vk -84) |
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15 | (define vl -60) |
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16 | (define vca 120) |
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17 | (define gk 2.5) |
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18 | (define gl 0.5) |
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19 | (define gca 1) |
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20 | (define c 2) |
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21 | (define v1 -1.2) |
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22 | (define v2 18) |
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23 | (define v3 12) |
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24 | (define v4 17) |
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25 | (define phi 0.0667) |
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26 | |
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27 | |
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28 | ;; State functions |
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29 | |
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30 | (define (minf v) (* 0.5 (+ 1 (tanh (/ (- v v1) v2))))) |
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31 | (define (winf v) (* 0.5 (+ 1 (tanh (/ (- v v3) v4))))) |
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32 | (define (lamw v) (* phi (cosh (/ (- v v3) (* 2 v4))))) |
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33 | |
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34 | ;; Model equations |
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35 | |
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36 | (define (rhs t yy) |
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37 | (let ((v (f64vector-ref yy 0)) |
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38 | (w (f64vector-ref yy 1))) |
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39 | |
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40 | (let ((ica (* gca (* (minf v) (- vca v)))) |
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41 | (ik (* gk (* w (- vk v ))))) |
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42 | |
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43 | (let ((dv (/ (+ Istim (* gl (- vl v)) ica ik) c)) |
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44 | (dw (* (lamw v) (- (winf v) w)))) |
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45 | |
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46 | (f64vector dv dw) |
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47 | |
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48 | )) |
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49 | )) |
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50 | |
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51 | (define (rhs/unsafe t yy yp _) |
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52 | (let ((v (pointer-f64-ref yy)) |
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53 | (w (pointer-f64-ref (pointer+-f64 yy 1)))) |
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54 | |
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55 | (let ((ica (* gca (* (minf v) (- vca v)))) |
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56 | (ik (* gk (* w (- vk v ))))) |
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57 | |
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58 | (let ((dv (/ (+ Istim (* gl (- vl v)) ica ik) c)) |
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59 | (dw (* (lamw v) (- (winf v) w)))) |
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60 | |
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61 | (pointer-f64-set! yp dv) |
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62 | (pointer-f64-set! (pointer+-f64 yp 1) dw) |
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63 | |
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64 | )) |
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65 | )) |
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66 | |
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67 | |
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68 | |
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69 | (define (main) |
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70 | |
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71 | (let ((yy (f64vector -60.899 0.0149)) ;; v w |
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72 | |
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73 | ;; Integration limits |
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74 | (t0 0.0) |
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75 | (tf TEND) |
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76 | (dt 1e-2)) |
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77 | |
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78 | ;; CVODE initialization |
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79 | (let ((solver (cvode-create-solver |
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80 | t0 tf yy rhs |
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81 | abstol: 1e-4 |
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82 | reltol: 1e-4))) |
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83 | |
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84 | ;; In loop, call CVodeSolve, print results, and test for error. |
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85 | |
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86 | (let recur ((tnext (+ t0 dt)) (iout 1)) |
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87 | |
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88 | (let ((flag (cvode-solve solver tnext))) |
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89 | (if (negative? flag) (error 'main "CVODE solver error" flag)) |
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90 | |
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91 | (if (< tnext tf) |
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92 | (recur (+ tnext dt) (+ 1 iout))) |
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93 | )) |
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94 | |
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95 | (let ((yy (cvode-yy solver))) |
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96 | (let ((v (f64vector-ref yy 0)) |
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97 | (w (f64vector-ref yy 1))) |
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98 | (assert (< (abs (- v -30.0536210523504)) 1e-12)) |
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99 | (assert (< (abs (- w 0.0402640532124851 )) 1e-12)))) |
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100 | |
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101 | (cvode-destroy-solver solver) |
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102 | |
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103 | ))) |
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104 | |
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105 | (define (main/unsafe) |
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106 | |
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107 | (let ((yy (f64vector -60.899 0.0149)) ;; v w |
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108 | |
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109 | ;; Integration limits |
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110 | (t0 0.0) |
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111 | (tf TEND) |
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112 | (dt 1e-2)) |
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113 | |
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114 | ;; CVODE initialization |
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115 | (let ((solver (cvode-create-solver/unsafe |
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116 | t0 tf yy rhs/unsafe |
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117 | abstol: 1e-4 |
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118 | reltol: 1e-4))) |
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119 | |
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120 | ;; In loop, call CVodeSolve, print results, and test for error. |
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121 | |
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122 | (let recur ((tnext (+ t0 dt)) (iout 1)) |
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123 | |
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124 | (let ((flag (cvode-solve solver tnext))) |
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125 | (if (negative? flag) (error 'main "CVODE solver error" flag)) |
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126 | |
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127 | (if (< tnext tf) |
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128 | (recur (+ tnext dt) (+ 1 iout))) |
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129 | )) |
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130 | |
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131 | (let ((yy (cvode-yy solver))) |
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132 | (let ((v (f64vector-ref yy 0)) |
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133 | (w (f64vector-ref yy 1))) |
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134 | (assert (< (abs (- v -30.0536210523504)) 1e-12)) |
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135 | (assert (< (abs (- w 0.0402640532124851 )) 1e-12)))) |
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136 | |
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137 | (cvode-destroy-solver solver) |
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138 | |
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139 | ))) |
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140 | |
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141 | |
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142 | (define (print-results solver t) |
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143 | (let ((yy (cvode-yy solver))) |
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144 | (printf "~A ~A ~A ~A ~A ~A~%" |
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145 | t |
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146 | (f64vector-ref yy 0) |
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147 | (f64vector-ref yy 1) |
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148 | (cvode-get-last-order solver) |
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149 | (cvode-get-num-steps solver) |
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150 | (cvode-get-last-step solver) |
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151 | ))) |
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152 | |
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153 | |
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154 | (main) |
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155 | (main/unsafe) |
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